Drug Information

Drug General Information
Drug ID
D05KUM
Former ID
DNC008848
Drug Name
DESMETHYLOLANZAPINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530215]
Formula
C16H18N4S
Canonical SMILES
CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCNCC4
InChI
1S/C16H18N4S/c1-11-10-12-15(20-8-6-17-7-9-20)18-13-4-2-3-5-14(13)19-16(12)21-11/h2-5,10,17-18H,6-9H2,1H3
InChIKey
CYCLMWMLGIRJQE-UHFFFAOYSA-N
PubChem Compound ID
9948206
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily H member 2 Target Info Inhibitor [530215]
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channels
WikiPathways SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium Channels
References
Ref 530215J Med Chem. 2009 Jul 23;52(14):4266-76.Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.
Ref 530215J Med Chem. 2009 Jul 23;52(14):4266-76.Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.

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