Drug Information

Drug General Information
Drug ID
D05HYL
Former ID
DIB002156
Drug Name
YM-022
Drug Type
Small molecular drug
Indication Gastrointestinal disease [ICD10:K00-K93] Terminated [543279], [545651]
Company
Yamanouchi Pharmaceutical Co Ltd
Formula
C32H28N4O3
InChI
InChI=1S/C32H28N4O3/c1-21-11-10-15-24(19-21)33-32(39)35-30-31(38)36(20-28(37)25-16-7-6-12-22(25)2)27-18-9-8-17-26(27)29(34-30)23-13-4-3-5-14-23/h3-19,30H,20H2,1-2H3,(H2,33,35,39)/t30-/m0/s1
InChIKey
YCXFHPUBGMMWJQ-PMERELPUSA-N
CAS Number
CAS 145084-28-2
PubChem Compound ID
122130
PubChem Substance ID
7980900, 10239956, 14787111, 14884979, 26753170, 29302577, 47359898, 47583725, 50064439, 57339969, 76981487, 91746453, 103339253, 103952505, 104415102, 129777651, 135076475, 135651339, 135698256, 162792679, 184538715, 198977762, 202827837, 228940607, 241036216, 252366099
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info Antagonist [534373]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 543279(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 888).
Ref 545651Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004033)
Ref 534373YM022, a potent and selective gastrin/CCK-B receptor antagonist, inhibits peptone meal-induced gastric acid secretion in Heidenhain pouch dogs. Dig Dis Sci. 1997 Apr;42(4):707-14.

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