Drug Information

Drug General Information
Drug ID
D05HMW
Former ID
DNC004005
Drug Name
2-(4-Dipropylamino-cyclohexylidene)-malononitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525701]
Formula
C15H23N3
Canonical SMILES
CCCN(CCC)C1CCC(=C(C#N)C#N)CC1
InChI
1S/C15H23N3/c1-3-9-18(10-4-2)15-7-5-13(6-8-15)14(11-16)12-17/h15H,3-10H2,1-2H3
InChIKey
FGVSZVRUGNMGKP-UHFFFAOYSA-N
PubChem Compound ID
10705550
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [525701]
D(3) dopamine receptor Target Info Inhibitor [525701]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 525701J Med Chem. 2000 Feb 24;43(4):756-62.Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype.
Ref 525701J Med Chem. 2000 Feb 24;43(4):756-62.Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.