Drug Information

Drug General Information
Drug ID
D05HKB
Former ID
DNC001236
Drug Name
RS 86
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Terminated [544694]
Formula
C11H19BrN2O2
Canonical SMILES
CCN1C(=O)CC2(C1=O)CCN(CC2)C.Br
InChI
1S/C11H18N2O2.BrH/c1-3-13-9(14)8-11(10(13)15)4-6-12(2)7-5-11;/h3-8H2,1-2H3;1H
InChIKey
RKVCNLSYEWDGNX-UHFFFAOYSA-N
CAS Number
CAS 51382-46-8
PubChem Compound ID
87933
PubChem Substance ID
10222735, 12012608, 44419166, 49961022, 57334412, 74773496, 103118368, 103671789, 104395225, 117386047, 126427228, 135046365, 163110353, 172648414, 198966769, 204407478
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Agonist [537751]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 544694Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000634)
Ref 537751The pharmacological assessment of RS 86 (2-ethyl-8-methyl-2,8-diazaspiro-[4,5]-decan-1,3-dion hydrobromide). A potent, specific muscarinic acetylcholine receptor agonist. Eur J Pharmacol. 1986 Jun 5;125(1):45-62.

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