Drug Information

Drug General Information
Drug ID
D05FUU
Former ID
DIB012715
Drug Name
Pratosartan
Synonyms
KD3-671; KT3-671
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Phase 3 [545261]
Company
Kotobuki Pharmaceutical Co Ltd
Formula
C25H26N6O
Canonical SMILES
n1(c2c(nc1CCC)CCCCC2=O)Cc1ccc(c2c(c3nnn[nH]3)cccc2)cc1
CAS Number
CAS 153804-05-8
PubChem Compound ID
9802561
Target and Pathway
Target(s) Type-1 angiotensin II receptor Target Info Antagonist [529390]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Renin-angiotensin system
Renin secretion
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway Angiotensin Metabolism
Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Allograft Rejection
GPCR ligand binding
GPCR downstream signaling
References
Ref 545261Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002623)
Ref 529390Clinical efficacy of a new angiotensin II type 1 receptor blocker, pratosartan, in hypertensive patients. Hypertens Res. 2008 Feb;31(2):281-7.

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