Drug Information

Drug General Information
Drug ID
D05EOW
Former ID
DIB019732
Drug Name
diarylpropionitril
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539867]
Formula
C15H13NO2
InChI
InChI=1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2
InChIKey
GHZHWDWADLAOIQ-UHFFFAOYSA-N
PubChem Compound ID
102614
PubChem Substance ID
4787349, 10232684, 15366572, 44432490, 50025873, 53790406, 53790908, 53801030, 75849427, 85787611, 91746498, 103371140, 104002116, 104367338, 125335435, 135059361, 135330769, 135610547, 162023054, 163134280, 206252313, 216088074, 228103496, 241182477, 242797341, 252159976, 252457911, 252467477
Target and Pathway
Target(s) Estrogen receptor beta Target Info Agonist [526191]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Pathway Interaction Database Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Reactome Nuclear Receptor transcription pathway
WikiPathways SIDS Susceptibility Pathways
Ovarian Infertility Genes
Integrated Pancreatic Cancer Pathway
Nuclear Receptors
References
Ref 539867(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2825).
Ref 526191Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem. 2001 Nov 22;44(24):4230-51.

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