Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05EKM
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| Former ID |
DIB002600
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| Drug Name |
FR-121196
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| Drug Type |
Small molecular drug
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| Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Terminated | [544870] | ||
| Company |
Fujisawa Pharmaceutical Co Ltd
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| Formula |
C12H16FN3O3S
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| Canonical SMILES |
S(=O)(=O)(NN1CCN(C(=O)C)CC1)c1ccc(cc1)F
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| CAS Number |
CAS 133920-65-7
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Somatostatin receptor type 4 | Target Info | Modulator | [533791] | |
| Somatostatin receptor type 2 | Target Info | Modulator | [533791] | ||
| Somatostatin receptor type 3 | Target Info | Modulator | [530618], [532210] | ||
| Somatostatin receptor type 5 | Target Info | Modulator | [533791] | ||
| Somatostatin receptor 1 | Target Info | Modulator | [530618], [532210] | ||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| PathWhiz Pathway | Gastric Acid Production | ||||
| References | |||||
| Ref 530618 | Mol Endocrinol. 2010 Feb;24(2):436-46. Epub 2010 Jan 5.Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation. | ||||
| Ref 532210 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | ||||
| Ref 533791 | Role of somatostatin in the augmentation of hippocampal long-term potentiation by FR121196, a putative cognitive enhancer. Eur J Pharmacol. 1993 Sep 7;241(1):27-34. | ||||
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