Drug Information

Drug General Information
Drug ID
D05BHF
Former ID
DIB003390
Drug Name
Masilukast
Synonyms
D-3523; MCC-847; ZD-3523
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 2 [547331]
Company
Zeneca Group plc
Formula
C31H32F3N3O5S
Canonical SMILES
S(=O)(=O)(NC(=O)c1cc(c(Cc2c3c(n(c2)C)ccc(c3)C(=O)NC[C@@<br />H](CC(F)(F)F)C)cc1)OC)c1c(C)cccc1
CAS Number
CAS 136564-68-6
PubChem Compound ID
204056
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Modulator [1572591]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 547331Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015230)
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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