Drug Information

Drug General Information
Drug ID
D04YLQ
Former ID
DNCL003313
Drug Name
AMG 334
Indication Migraine [ICD9: 346; ICD10:G43] Phase 2 [524809]
Company
Amgen
Target and Pathway
Target(s) Calcitoningene-related peptide type 1 receptor Target Info Modulator [544443]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Reactome G alpha (s) signalling events
Calcitonin-like ligand receptors
WikiPathways GPCRs, Class B Secretin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 524809ClinicalTrials.gov (NCT02174861) A Study to Assess the Long-term Safety and Efficacy of AMG 334 in Chronic Migraine Prevention.. U.S. National Institutes of Health.
Ref 544443EHMTI-0315. AMG 334, the first potent and selective human monoclonal antibody antagonist against the CGRP receptor. J Headache Pain. 2014; 15(Suppl 1): G43.

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