Drug Information

Drug General Information
Drug ID
D04VWL
Former ID
DIB006855
Drug Name
Cannabinoid 1 antagonists
Synonyms
Cannabinoid 1 antagonists (obesity); Cannabinoid 1 antagonists (obesity), Gedeon Richter
Indication Obesity [ICD9: 278; ICD10:E66] Investigative [552049]
Company
Gedeon Richter Ltd
Canonical SMILES
c1cccc2c1N(C(c1n2ccc1)c1ccc(cc1)Cl)C(=O)CN(C(=O)C(C)Cl)<br />CCCC
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Antagonist [543877]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 552049Chemical and biological investigation of cyclopropyl containing diaryl-pyrazole-3-carboxamides as novel and potent cannabinoid type 1 receptor antagonists. J Med Chem. 2009 Jul 23;52(14):4329-37
Ref 543877(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56).

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