Drug Information

Drug General Information
Drug ID
D04QUX
Former ID
DIB011713
Drug Name
PF-446687
Synonyms
PF-00446687; PF-2336652
Indication Female sexual dysfunction [ICD9: 302.7; ICD10:F52] Phase 2 [522609]
Company
Pfizer Inc
Canonical SMILES
[C@@H]1([C@@H](CN(C1)C(C)(C)C)c1ccc(cc1F)F)C(=O)N1C[C@H<br />]([C@](c2ccccc2)([C@H](C1)C)O)C.Cl
Target and Pathway
Target(s) Melanocortin-4 receptor Target Info Modulator [533131]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Syndecan-3-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 522609ClinicalTrials.gov (NCT00862888) Study to Investigate Effect of a New Drug (PF-00446687) in Males Suffering From Erectile Dysfunction. U.S. National Institutes of Health.
Ref 533131Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole. Neuropsychopharmacology. 2015 Jul;40(8):1856-65.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.