Drug Information

Drug General Information
Drug ID
D04PYQ
Former ID
DNC012020
Drug Name
PIPEROXAN
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533545]
Formula
C14H19NO2
Canonical SMILES
C1CCN(CC1)CC2COC3=CC=CC=C3O2
InChI
1S/C14H19NO2/c1-4-8-15(9-5-1)10-12-11-16-13-6-2-3-7-14(13)17-12/h2-3,6-7,12H,1,4-5,8-11H2
InChIKey
LYKMMUBOEFYJQG-UHFFFAOYSA-N
CAS Number
CAS 59-39-2
PubChem Compound ID
6040
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Inhibitor [533545]
Alpha-2B adrenergic receptor Target Info Inhibitor [533545]
Alpha-2A adrenergic receptor Target Info Inhibitor [533545]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 533545J Med Chem. 1982 Dec;25(12):1389-401.alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs.
Ref 533545J Med Chem. 1982 Dec;25(12):1389-401.alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs.

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