Drug Information

Drug General Information
Drug ID
D04ODQ
Former ID
DIB006853
Drug Name
447C88
Synonyms
BW-447C88
Indication Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] Discontinued in Phase 1 [545135]
Company
GlaxoSmithKline Inc
Canonical SMILES
c1(c(cc(cc1CCc1ccc(CC(C)(C)C)cc1)F)F)NC(=O)NCCCCCCC
CAS Number
CAS 130400-16-7
Target and Pathway
Target(s) Liver carboxylesterase Target Info Modulator [534137]
KEGG Pathway Drug metabolism - other enzymes
Metabolic pathways
Pathway Interaction Database E2F transcription factor network
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Heroin metabolism
Irinotecan Pathway
Fluoropyrimidine Activity
Phase I biotransformations, non P450
References
Ref 545135Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002257)
Ref 534137The tolerability, pharmacokinetics and lack of effect on plasma cholesterol of 447C88, an AcylCoA: Cholesterol Acyl Transferase (ACAT) inhibitor with low bioavailability, in healthy volunteers. Eur JClin Pharmacol. 1995;49(3):243-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.