Drug Information

Drug General Information
Drug ID
D04NPX
Former ID
DIB004873
Drug Name
ZD-1611
Synonyms
Endothelin antagonist, Zeneca
Indication Hypotension [ICD9: 458, 796.3; ICD10:I95] Discontinued in Phase 1 [546553]
Company
AstraZeneca plc
Canonical SMILES
S(=O)(=O)(Nc1c(nc(cn1)C)OC)c1c(nccc1)c1ccc(CC(C(=O)O)(C<br />)C)cc1
CAS Number
CAS 186497-38-1
Target and Pathway
Target(s) Endothelin-1 receptor Target Info Antagonist [525566]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Renin secretion
Pathways in cancer
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Endothelin signaling pathway
Pathway Interaction Database Endothelins
EGFR-dependent Endothelin signaling events
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 546553Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008908)
Ref 525566Pharmacological profile of ZD1611, a novel, orally active endothelin ETA receptor antagonist. J Pharmacol Exp Ther. 1999 Sep;290(3):1085-91.

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