TTD | Drug: D04NPP

Drug General Information
Drug ID	D04NPP
Former ID	DNCL001638
Drug Name	SLX-2101
Indication	Erectile dysfunction; Hypertension; Raynaud's disease [ICD9: 302.72, 607.84, 401, 443; ICD10:F52.2, N48.4, I10-I16, I73.0]		Discontinued in Phase 2	[548157]
Company	Kadmon Pharmaceuticals; Nano Terra
Target and Pathway
Target(s)	CGMP-specific 3',5'-cyclic phosphodiesterase	Target Info	Inhibitor	[529481]
KEGG Pathway	Purine metabolism
KEGG Pathway	cGMP-PKG signaling pathway
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
Reactome	cGMP effects
References
Ref 548157	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022583)
Ref 529481	Novel phosphodiesterase-5 (PDE5) inhibitors in the alleviation of erectile dysfunction due to diabetes and ageing-induced oxidative stress. Expert Opin Investig Drugs. 2008 Jun;17(6):855-64.

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Drug Information