Drug Information

Drug General Information
Drug ID
D04MYO
Former ID
DIB002133
Drug Name
ABN-912
Synonyms
Anti-CD46 mAb, Novartis; Anti-MCP1 monoclonal antibody, Novartis
Drug Type
Antibody
Indication Asthma [ICD10:J45] Discontinued in Phase 1 [547919]
Company
Novartis AG
Target and Pathway
Target(s) C-C motif chemokine 2 Target Info [528332]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NOD-like receptor signaling pathway
TNF signaling pathway
Chagas disease (American trypanosomiasis)
Malaria
Influenza A
Herpes simplex infection
Rheumatoid arthritis
NetPath Pathway IL9 Signaling Pathway
IL5 Signaling Pathway
IL1 Signaling Pathway
TSH Signaling Pathway
TWEAK Signaling Pathway
IL4 Signaling Pathway
TNFalpha Signaling Pathway
TSLP Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database GMCSF-mediated signaling events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
AP-1 transcription factor network
IL23-mediated signaling events
Reactome Chemokine receptors bind chemokines
ATF4 activates genes
WikiPathways IL1 and megakaryotyces in obesity
Activation of Genes by ATF4
Spinal Cord Injury
Oncostatin M Signaling Pathway
TNF alpha Signaling Pathway
TWEAK Signaling Pathway
IL-1 signaling pathway
GPCR ligand binding
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 547919Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020409)
Ref 528332A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis. Arthritis Rheum. 2006 Aug;54(8):2387-92.

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