Drug Information

Drug General Information
Drug ID
D04MVR
Former ID
DIB018725
Drug Name
A-794282
Synonyms
compound 1n [PMID: 16279797]; A 794282; A794282
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527859]
Formula
C19H18N4OS
InChI
InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3
InChIKey
VCUKKMIXURRDKL-UHFFFAOYSA-N
PubChem Compound ID
11530404
PubChem Substance ID
16632456, 23656036, 42648433, 77987488, 103499678, 104062559, 126640045, 137348847, 178102832, 180187710, 233769439, 241156331, 243236077
Target and Pathway
Target(s) Metabotropicglutamate receptor 1 Target Info Modulator (allosteric modulator) [527859]
KEGG Pathway Calcium signaling pathway
FoxO signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 527859Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists. J Med Chem. 2005 Nov 17;48(23):7374-88.
Ref 527859Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists. J Med Chem. 2005 Nov 17;48(23):7374-88.

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