Drug Information

Drug General Information
Drug ID
D04MSI
Former ID
DIB021052
Drug Name
threo-3-methylglutamate
Synonyms
(+/-)-threo-3-methylglutamic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467811]
Formula
C6H11NO4
InChI
InChI=1S/C6H11NO4/c1-3(2-4(8)9)5(7)6(10)11/h3,5H,2,7H2,1H3,(H,8,9)(H,10,11)
InChIKey
FHJNAFIJPFGZRI-UHFFFAOYSA-N
PubChem Compound ID
237657
PubChem Substance ID
96259, 120842, 146710, 798309, 5316156, 9388314, 11448261, 14843092, 30036885, 76567041, 103131332, 104465180, 117369568, 126465870, 127847554, 135252821, 137087963, 138906426, 163126460, 164762505, 178101294, 217801728, 226727433, 249534248, 249916734
Target and Pathway
Target(s) Excitatory amino acid transporter 2 Target Info Inhibitor [534384]
Excitatory amino acid transporter 4 Target Info Inhibitor [526025]
PANTHER Pathway Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
WikiPathways Amyotrophic lateral sclerosis (ALS)
References
Ref 467811(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4573).
Ref 526025Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J Neurochem. 2001 Apr;77(2):550-7.
Ref 534384Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol Pharmacol. 1997 May;51(5):809-15.

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