Drug Information

Drug General Information
Drug ID
D04KRV
Former ID
DNCL002153
Drug Name
Iofolastat I-124
Synonyms
Trofex (TN)
Drug Type
Small molecular drug
Indication Prostate cancer [ICD9: 185; ICD10:C61] Phase 1 [548537]
Company
Molecular Insight Pharmaceuticals
Formula
C19H26IN3O7
Canonical SMILES
C1=CC(=CC=C1CNCCCCC(C(=O)O)NC(=O)NC(CCC(=O)O)C(=O)O)I
InChI
1S/C19H26IN3O7/c20-13-6-4-12(5-7-13)11-21-10-2-1-3-14(17(26)27)22-19(30)23-15(18(28)29)8-9-16(24)25/h4-7,14-15,21H,1-3,8-11H2,(H,24,25)(H,26,27)(H,28,29)(H2,22,23,30)/t14-,15-/m0/s1/i20-4
InChIKey
OXUUJYOSVPMNKP-ZANJDRPYSA-N
PubChem Compound ID
25194767
PubChem Substance ID
57303595, 85037977, 103628223, 135626790, 138218262, 163642994, 198948532, 237936272
Target and Pathway
Target(s) Glutamate carboxypeptidase II Target Info Inhibitor [531520]
KEGG Pathway Alanine, aspartate and glutamate metabolism
Metabolic pathways
Vitamin digestion and absorption
NetPath Pathway TCR Signaling Pathway
TNFalpha Signaling Pathway
Reactome Amino acid synthesis and interconversion (transamination)
WikiPathways One Carbon Metabolism
References
Ref 548537Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026421)
Ref 531520123I-MIP-1072, a small-molecule inhibitor of prostate-specific membrane antigen, is effective at monitoring tumor response to taxane therapy. J Nucl Med. 2011 Jul;52(7):1087-93.

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