Drug Information

Drug General Information
Drug ID
D04IKS
Former ID
DNC013390
Drug Name
7-(3-methoxyphenyl)-2-methyl-1,6-naphthyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529101]
Formula
C16H14N2O
Canonical SMILES
CC1=NC2=CC(=NC=C2C=C1)C3=CC(=CC=C3)OC
InChI
1S/C16H14N2O/c1-11-6-7-13-10-17-15(9-16(13)18-11)12-4-3-5-14(8-12)19-2/h3-10H,1-2H3
InChIKey
FNFGNQRSMXJCIJ-UHFFFAOYSA-N
PubChem Compound ID
44434751
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [529101]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 529101Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. Epub 2007 Sep 29.Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists.
Ref 529101Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. Epub 2007 Sep 29.Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.