Drug Information

Drug General Information
Drug ID
D04IKF
Former ID
DIB004564
Drug Name
18F-LMI-1195
Synonyms
LMI-1195; Flourine-18-LMI-1195; Fluorine-18-based PET imaging agent (intravenous, heart failure), Lantheus; 18F-based PET imaging agent (intravenous, heart failure), Lantheus
Indication Heart failure [ICD9: 428; ICD10:I50] Phase 2 [522972]
Company
Lantheus medical imaging
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Enhancer [532351]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 522972ClinicalTrials.gov (NCT01085175) Trial to Determine Imaging Parameters of LMI1195 in Heart Failure Patients at Low and High Risk of Defibrillator Firing. U.S. National Institutes of Health.
Ref 532351Assessment of the 18F-labeled PET tracer LMI1195 for imaging norepinephrine handling in rat hearts. J Nucl Med. 2013 Jul;54(7):1142-6.

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