Drug Information

Drug General Information
Drug ID
D04HZX
Former ID
DIB017025
Drug Name
CCX-832
Synonyms
ChemR2 receptor antagonist (inflammation), ChemoCentryx/GlaxoSmithKline
Indication Psoriasis [ICD9: 696; ICD10:L40] Discontinued in Phase 1 [548366]
Company
ChemoCentryx Inc
Target and Pathway
Target(s) C-C chemokine receptor type 8 Target Info Antagonist [544435]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Viral carcinogenesis
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 548366Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025006)
Ref 544435Increased Expression of Chemerin in Squamous Esophageal Cancer Myofibroblasts and Role in Recruitment of Mesenchymal Stromal Cells. PLoS One. 2014; 9(8): e104877.

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