Drug Information

Drug General Information
Drug ID
D04GJN
Former ID
DAP000861
Drug Name
Megestrol
Synonyms
Chronopil; Megestrolo; Megestrolo [DCIT]; Chronopil (TN); Megace (TN); Megestrol (INN); Megestrol [INN:BAN]; Megestrolum [INN-Latin]; (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one; 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione
Drug Type
Small molecular drug
Indication Advanced breast carcinoma; Advanced endometrium carcinoma [ICD9: 174, 175, 182.0; ICD10:C50, C54.1] Approved [536165]
Therapeutic Class
Anticancer Agents
Company
Bristol Myers Squibb
Formula
C22H30O3
Canonical SMILES
CC1=CC2C(CCC3(C2CCC3(C(=O)C)O)C)C4(C1=CC(=O)CC4)C
InChI
1S/C22H30O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h11-12,16-18,25H,5-10H2,1-4H3/t16-,17+,18+,20-,21+,22+/m1/s1
InChIKey
VXIMPSPISRVBPZ-NWUMPJBXSA-N
CAS Number
CAS 3562-63-8
PubChem Compound ID
19090
PubChem Substance ID
9331, 7979883, 8164241, 14802482, 29286707, 50019471, 50361253, 57330277, 76715644, 85300840, 96024857, 104346944, 129540564, 134338140, 134984412, 137005329, 140917517, 152344100, 160963698, 162177766, 175267131, 179116767, 184595304, 211535765, 226399998, 249866672, 252411513
ChEBI ID
ChEBI:6722
SuperDrug ATC ID
G03AC05; G03DB02; L02AB01
SuperDrug CAS ID
cas=003562638
Target and Pathway
Target(s) Progesterone receptor Target Info Binder [535883]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 536165Hormonal therapy in epithelial ovarian cancer. Expert Rev Anticancer Ther. 2006 Jan;6(1):43-7.
Ref 535883Focus on anastrozole and breast cancer. Curr Med Res Opin. 2003;19(8):683-8.

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