Drug Information

Drug General Information
Drug ID
D04GFX
Former ID
DIB020417
Drug Name
MRS1132
Synonyms
3-chloroflavone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540616]
Formula
C15H9ClO2
InChI
InChI=1S/C15H9ClO2/c16-13-14(17)11-8-4-5-9-12(11)18-15(13)10-6-2-1-3-7-10/h1-9H
InChIKey
FHXDSQYFCFWKAW-UHFFFAOYSA-N
PubChem Compound ID
736736
PubChem Substance ID
955247, 3276408, 3331934, 5380106, 8043798, 9311460, 15515905, 17076369, 35412648, 80484603, 88704493, 103273862, 103948352, 106128313, 109887413, 118135253, 125780219, 126709527, 127849679, 135650644, 137160282, 141089787, 144023896, 169461969, 181738853, 226465887
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Antagonist [534145]
Adenosine A1 receptor Target Info Antagonist [534145]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholismhsa04022:cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Morphine addiction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
GPCR downstream signaling
References
Ref 540616(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 400).
Ref 534145J Med Chem. 1996 Jun 7;39(12):2293-301.Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.