Drug Information

Drug General Information
Drug ID
D04ENK
Former ID
DNC001415
Drug Name
TCV-309
Drug Type
Small molecular drug
Indication Septic shock [ICD9: 785.52; ICD10:A41.9] Discontinued in Phase 2 [545100]
Formula
C30H34BrN5O7
Canonical SMILES
CCC[N+]1=C(C=C(C=C1)C(=O)N(CCC(=O)NCCOC(=O)N2CCC3=CC=CC<br />=C3C2)C4=CC=CC=C4)Br.[N+](=O)([O-])[O-]
InChI
1S/C30H33BrN4O4.NO3/c1-2-16-33-17-13-24(21-27(33)31)29(37)35(26-10-4-3-5-11-26)19-14-28(36)32-15-20-39-30(38)34-18-12-23-8-6-7-9-25(23)22-34;2-1(3)4/h3-11,13,17,21H,2,12,14-16,18-20,22H2,1H3;/q;-1/p+1
InChIKey
XBPVPWDSUWHDIC-UHFFFAOYSA-O
PubChem Compound ID
115231
PubChem Substance ID
29296756, 50068129, 57339066, 75256363, 104397907
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 545100Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002130)

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