Drug Information

Drug General Information
Drug ID
D04DHD
Former ID
DIB019850
Drug Name
fasidotrilat
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541639]
Formula
C14H17NO5S
InChI
InChI=1S/C14H17NO5S/c1-8(14(17)18)15-13(16)10(6-21)4-9-2-3-11-12(5-9)20-7-19-11/h2-3,5,8,10,21H,4,6-7H2,1H3,(H,15,16)(H,17,18)/t8-,10+/m0/s1
InChIKey
TXSINLUUGRGAJO-WCBMZHEXSA-N
PubChem Compound ID
6450805
PubChem Substance ID
43041850, 50876527, 57370221, 114525900, 135259126
Target and Pathway
Target(s) Angiotensin-converting enzyme Target Info Inhibitor [528270]
Neutral endopeptidase Target Info Inhibitor [528271]
KEGG Pathway Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)hsa04614:Renin-angiotensin system
Hematopoietic cell lineage
Protein digestion and absorption
Alzheimer's disease
NetPath Pathway EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to AngiotensinsR-HSA-2022377:Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to AngiotensinsWP2729:Metabolism of Angiotensinogen to Angiotensins
Primary Focal Segmental Glomerulosclerosis FSGS
Alzheimers Disease
References
Ref 541639(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6502).
Ref 528270Protease inhibitors in the clinic. Med Chem. 2005 Jan;1(1):71-104.
Ref 528271Modelling of aldose reductase inhibitory activity of pyrrol-1-yl-acetic acid derivatives by means of multivariate statistics. Med Chem. 2005 Jul;1(4):321-6.

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