Drug Information

Drug General Information
Drug ID
D04CON
Former ID
DIB015958
Drug Name
SL-89.0591
Indication Prostate disease [ICD10:N42.9] Discontinued in Phase 2 [545536]
Company
Synthelabo
Canonical SMILES
N1(c2cc(ccc2OC)Cl)CCN(CC1)CCCNc1nc(C(=O)N)ccn1
CAS Number
CAS 194674-19-6
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Modulator [525538]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 545536Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003628)
Ref 525538Effects of alpha1-adrenoceptor antagonists on agonist and tilt-induced changes in blood pressure: relationships to uroselectivity. Eur J Pharmacol. 1999 May 28;373(1):51-62.

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