Drug Information

Drug General Information
Drug ID
D04BSZ
Former ID
DIB010673
Drug Name
PD-0204318
Synonyms
PD-0183764
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Terminated [547298]
Company
Parke-Davis & Co
Canonical SMILES
N(CC=C(C)C)(C1CCN(CC1)Cc1ccc(N(C)C)cc1)c1ccc(cc1)CCC(C)<br />(C)C
CAS Number
CAS 241499-17-2
Target and Pathway
Target(s) Voltage-dependent N-type calcium channel Target Info Antagonist [550906]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Synaptic vesicle cycle
Retrograde endocannabinoid signaling
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Taste transduction
Type II diabetes mellitus
Morphine addiction
Nicotine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group II pathway
Thyrotropin-releasing hormone receptor signaling pathway
Endogenous cannabinoid signaling
GABA-B receptor II signaling
Reactome Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
WikiPathways Calcium Regulation in the Cardiac Cell
Synaptic Vesicle Pathway
References
Ref 547298Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014952)
Ref 550906US patent application no. 2012,0172,429, Permanently charged sodium and calcium channel blockers as anti- inflammatory agents.

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