Drug Information

Drug General Information
Drug ID
D03ZUB
Former ID
DIB020842
Drug Name
Ro67-7476
Synonyms
Ro67-7476; Ro-677476; Ro 677476
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538863]
Formula
C17H18FNO2S
InChI
InChI=1S/C17H18FNO2S/c1-13-4-10-16(11-5-13)22(20,21)19-12-2-3-17(19)14-6-8-15(18)9-7-14/h4-11,17H,2-3,12H2,1H3
InChIKey
DAEHFYNGSSBGSS-UHFFFAOYSA-N
PubChem Compound ID
17950211
PubChem Substance ID
36735135, 47252754, 54268514, 57276701, 109469363, 118274534, 123916389, 124594922, 127705134, 135541468, 135650924, 169209951, 225092454, 229722282
Target and Pathway
Target(s) Metabotropicglutamate receptor 1 Target Info Modulator (allosteric modulator) [526172]
KEGG Pathway Calcium signaling pathway
FoxO signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538863(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1388).
Ref 526172Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13402-7. Epub 2001 Oct 23.

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