Drug Information

Drug General Information
Drug ID
D03YLX
Former ID
DNC011843
Drug Name
3-Methyl-9H-beta-carboline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533745]
Formula
C12H10N2
Canonical SMILES
CC1=NC=C2C(=C1)C3=CC=CC=C3N2
InChI
1S/C12H10N2/c1-8-6-10-9-4-2-3-5-11(9)14-12(10)7-13-8/h2-7,14H,1H3
InChIKey
XOHBPUCYRSORIZ-UHFFFAOYSA-N
PubChem Compound ID
13315103
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor Target Info Inhibitor [533745]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [533745]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [533745]
Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [533745]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP706:SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 533745J Med Chem. 1994 Dec 23;37(26):4576-80.Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor.
Ref 533745J Med Chem. 1994 Dec 23;37(26):4576-80.Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor.

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