Drug Information

Drug General Information
Drug ID
D03XWL
Former ID
DIB009801
Drug Name
Low dose ITI-007
Synonyms
ITI-722; Low dose ITI-007 (oral, sleep maintenance insomnia/sleep disorder); Low dose ITI-007 (oral, sleep maintenance insomnia/sleep disorder), Intra-Cellular Therapies; 5-HT 2a receptor antagonist (oral, sleep maintenance insomnia/sleep disorders), Intra-Cellular Therapies
Indication Schizophrenia [ICD9: 295; ICD10:F20] Phase 3 [548546]
Company
Bristol-Myers Squibb Co
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Antagonist [526792], [551041]
Sodium-dependent serotonin transporter Target Info Antagonist [551041]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP727:Monoamine Transport
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 548546Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026498)
Ref 526792Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598). J Pharmacol Exp Ther. 1992 Jan;260(1):146-59.
Ref 551041Clinical pipeline report, company report or official report of Intra-Cellular Therapies, Inc.

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