Drug Information

Drug General Information
Drug ID
D03XOC
Former ID
DAP000148
Drug Name
Trilostane
Synonyms
Desopan; Desopan (TN); Modrenal (TN); Vetoryl (TN); Vetoryl, Trilostane; Win-24540; Trilostane (JAN/USAN); (4alpha,5alpha,17beta)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile; 3,17beta-dihydroxy-4alpha,5-epoxy-5alpha-androst-2-ene-2-carbonitrile
Drug Type
Small molecular drug
Indication Cushing's disease [ICD9: 255; ICD10:E24.0] Approved [538514], [541930]
Company
Dechra Pharmaceuticals
Formula
C20H27NO3
InChI
InChI=1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1
InChIKey
KVJXBPDAXMEYOA-CXANFOAXSA-N
CAS Number
CAS 13647-35-3
PubChem Compound ID
656583
PubChem Substance ID
582970, 7848243, 9268061, 14753126, 14850960, 46507062, 48416665, 53789389, 56352900, 57408348, 77191778, 92716671, 99437135, 103770890, 113527831, 124757227, 125164031, 126591224, 126622687, 126654263, 127324070, 127324071, 127324072, 127324073, 127324074, 134337470, 134990249, 135692137, 136946482, 137005257, 143492476, 144206007, 144212723, 152103462, 152164604, 152242918, 160964442, 162170394, 163138502, 164194095, 165702349, 170465836, 175265964, 176262060, 176484985, 178103456, 179149866, 196105623, 210275073, 210280711
ChEBI ID
ChEBI:32260
SuperDrug ATC ID
H02CA01
SuperDrug CAS ID
cas=013647353
Target and Pathway
Target(s) Estrogen receptor beta Target Info Modulator [556264]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Pathway Interaction Database Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Reactome Nuclear Receptor transcription pathway
WikiPathways SIDS Susceptibility Pathways
Ovarian Infertility Genes
Integrated Pancreatic Cancer Pathway
Nuclear Receptors
References
Ref 538514FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018719.
Ref 541930(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6850).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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