Drug Information

Drug General Information
Drug ID
D03XHS
Former ID
DIB012795
Drug Name
ACT-178882
Synonyms
MK-1597
Indication Cardiovascular disorder [ICD10:I00-I99] Phase 1 [548839]
Company
Actelion Ltd
Canonical SMILES
c1c(ccc(n1)OCCOc1c(cc(cc1Cl)C)Cl)[C@@H]1[C@H](CNCC1)C(=<br />O)N(C1CC1)Cc1c(ccc(c1)CCOC)Cl
Target and Pathway
Target(s) Renin, renal Target Info Inhibitor [532219]
KEGG Pathway Renin-angiotensin system
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 548839Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029409)
Ref 532219Drug-drug interaction study of ACT-178882, a new renin inhibitor, and diltiazem in healthy subjects. Clin Drug Investig. 2013 Mar;33(3):207-13.

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