Drug Information

Drug General Information
Drug ID
D03XBB
Former ID
DIB012839
Drug Name
DX-2400
Synonyms
DX-2410; MMP inhibitors (fully human antibodies), Dyax
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Investigative [543455]
Company
Dyax Corp
Target and Pathway
Target(s) Matrix metalloproteinase-14 Target Info Inhibitor [543455]
KEGG Pathway TNF signaling pathway
GnRH signaling pathway
PANTHER Pathway Alzheimer disease-presenilin pathway
Pathway Interaction Database HIF-2-alpha transcription factor network
Signaling events mediated by focal adhesion kinase
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Senescence and Autophagy in Cancer
Activation of Matrix Metalloproteinases
Degradation of collagen
AGE/RAGE pathway
Matrix Metalloproteinases
References
Ref 543455(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1638).
Ref 543455(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1638).

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