Drug Information

Drug General Information
Drug ID
D03POY
Former ID
DIB003158
Drug Name
ISIS-AR
Drug Type
Antisense drug
Indication Prostate cancer [ICD9: 185; ICD10:C61] Phase 1 [551936]
Target and Pathway
Target(s) mRNA of androgen receptor Target Info [551942]
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 551936Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
Ref 551942Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.

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