Drug Information

Drug General Information
Drug ID
D03OFN
Former ID
DIB011444
Drug Name
NK-314
Synonyms
Topoisomerase modulator, Nippon Kayaku
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [547889]
Company
Nippon Kayaku Co Ltd
Canonical SMILES
[n+]12c3c(c4c(c1CCC2)c(c(cc4)OC)O)ccc1c3cc2c(c1)OCO2.[C<br />l-]
Target and Pathway
Target(s) DNA topoisomerase II Target Info Modulator [536762]
References
Ref 547889Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020174)
Ref 536762NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform. J Biol Chem. 2008 Aug 29;283(35):23711-20. Epub 2008 Jul 2.

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