Drug Information

Drug General Information
Drug ID
D03NWV
Former ID
DNC011932
Drug Name
1-(2-Ethoxy-phenyl)-piperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533134]
Formula
C12H18N2O
Canonical SMILES
CCOC1=CC=CC=C1N2CCNCC2
InChI
1S/C12H18N2O/c1-2-15-12-6-4-3-5-11(12)14-9-7-13-8-10-14/h3-6,13H,2,7-10H2,1H3
InChIKey
FBQIUSDQWOLCNY-UHFFFAOYSA-N
PubChem Compound ID
83357
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Inhibitor [533134]
5-hydroxytryptamine 1D receptor Target Info Inhibitor [533134]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 533134J Med Chem. 1989 May;32(5):1052-6.Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Ref 533134J Med Chem. 1989 May;32(5):1052-6.Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.

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