Drug Information

Drug General Information
Drug ID
D03LVL
Former ID
DIB019948
Drug Name
GSK2193874
Synonyms
GSK 2193874; GSK-2193874
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541600]
Formula
C37H38BrF3N4O
InChI
InChI=1S/C37H38BrF3N4O/c38-28-12-13-30-32(23-28)42-34(25-8-7-11-27(22-25)37(39,40)41)31(24-44-20-14-29(15-21-44)45-18-5-2-6-19-45)33(30)35(46)43-36(16-17-36)26-9-3-1-4-10-26/h1,3-4,7-13,22-23,29H,2,5-6,14-21,24H2,(H,43,46)
InChIKey
UIVOZBSCHXCGPS-UHFFFAOYSA-N
PubChem Compound ID
53464483
PubChem Substance ID
126490592, 178103079, 228518108, 241377328, 252158602
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily V member 4 Target Info Blocker (channel blocker) [532109]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome TRP channels
References
Ref 541600(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6465).
Ref 532109An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. Sci Transl Med. 2012 Nov 7;4(159):159ra148.

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