Drug Information

Drug General Information
Drug ID
D03LDH
Former ID
DNC004833
Drug Name
1-Benzyl-4-chroman-2-ylmethyl-piperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527368]
Formula
C21H26N2O
Canonical SMILES
C1CC2=CC=CC=C2OC1CN3CCN(CC3)CC4=CC=CC=C4
InChI
1S/C21H26N2O/c1-2-6-18(7-3-1)16-22-12-14-23(15-13-22)17-20-11-10-19-8-4-5-9-21(19)24-20/h1-9,20H,10-17H2
InChIKey
AJZBPCAHQHCXMX-UHFFFAOYSA-N
PubChem Compound ID
10758200
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Inhibitor [527368]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 527368J Med Chem. 2005 Jan 13;48(1):266-73.Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.
Ref 527368J Med Chem. 2005 Jan 13;48(1):266-73.Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.

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