Drug Information

Drug General Information
Drug ID
D03JHJ
Former ID
DIB008335
Drug Name
FK-352
Synonyms
FK-325B; FK-352B
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Discontinued in Phase 2 [545925]
Company
Fujisawa Pharmaceutical Co Ltd
Formula
C23H23N3O3
Canonical SMILES
c1(c(nn2c1cccc2)c1ccccc1)/C=C/C(=O)N1[C@@H](CC(=O)O)CCC<br />C1
CAS Number
CAS 143881-08-7
PubChem Compound ID
6442241
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Antagonist [527956]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 545925Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005374)
Ref 527956Adenosine A1 receptor antagonist improves intradialytic hypotension. Kidney Int. 2006 Mar;69(5):877-83.

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