Drug Information

Drug General Information
Drug ID
D03EFD
Former ID
DIB011163
Drug Name
KT-95
Synonyms
KT-90
Indication Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51] Terminated [546410]
Company
Toho Chemical Industry Co
Canonical SMILES
[C@]123c4c5O[C@H]1[C@H](SC(=O)C)CC[C@H]2[C@H](N(CC1CC1)<br />CC3)Cc4ccc5OC(=O)C
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Modulator [543763]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 546410Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007966)
Ref 543763(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 318).

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