Drug Information

Drug General Information
Drug ID
D03DVJ
Former ID
DIB002878
Drug Name
Propylhexedrine
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Approved [551871]
Formula
C10H22ClN
Canonical SMILES
CNC(C)CC1CCCCC1
InChI
1S/C10H21N/c1-9(11-2)8-10-6-4-3-5-7-10/h9-11H,3-8H2,1-2H3
InChIKey
JCRIVQIOJSSCQD-UHFFFAOYSA-N
PubChem Compound ID
102541
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Modulator [533622], [551871]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 533622Airway compromise and delayed death following attempted central vein injection of propylhexedrine. J Emerg Med. 1994 Nov-Dec;12(6):795-7.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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