Drug Information

Drug General Information
Drug ID
D03DET
Former ID
DIB020909
Drug Name
SB 714786
Synonyms
SB-714786; SB714786
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542675]
Formula
C26H28N4O
InChI
InChI=1S/C26H28N4O/c1-20-10-11-23-24(28-20)8-3-9-25(23)31-18-17-29-13-15-30(16-14-29)19-22-6-2-5-21-7-4-12-27-26(21)22/h2-12H,13-19H2,1H3
InChIKey
RMCSKUADBRROSI-UHFFFAOYSA-N
PubChem Compound ID
10287730
PubChem Substance ID
15293693, 22663353, 35559725, 75175905, 103463576, 125092763, 135651017, 151981921, 160827889, 163093367, 163361144, 163391353, 163912806, 172880988, 206245872, 223590538, 232127101, 242060001, 247556385, 252216276, 252508793
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Antagonist [527551]
5-hydroxytryptamine 1D receptor Target Info Antagonist [527551]
5-hydroxytryptamine 1A receptor Target Info Antagonist [527551]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
GPCR downstream signaling
References
Ref 542675(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 77).
Ref 527551Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist. J Med Chem. 2005 May 19;48(10):3478-80.

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