Drug Information

Drug General Information
Drug ID
D03DEI
Former ID
DAP000794
Drug Name
Sulfinpyrazone
Synonyms
Anturan; Anturane; Anturanil; Anturano; Anturen; Anturidin; Diphenylpyrazone; Enturan; Enturen; Novopyrazone; Sulfinpirazona; Sulfinpyrazine; Sulfinpyrazon; Sulfinpyrazonum; Sulfoxyphenylpyrazolidin; Sulfoxyphenylpyrazolidine; Sulphinpyrazone; Apo Sulfinpyrazone; Apotex Brand of Sulfinpyrazone; Novartis Brand of Sulfinpyrazone; Nu Pharm Brand of Sulfinpyrazone; Nu Sulfinpyrazone; G 28315; Anturane (TN); Apo-Sulfinpyrazone; G 28,315; Nu-Pharm Brand of Sulfinpyrazone; Nu-Sulfinpyrazone; Sulfinpirazona [INN-Spanish]; Sulfinpyrazone (SPZ); Sulfinpyrazonum [INN-Latin]; USAF GE-13; Sulfinpyrazone [USAN:INN:JAN]; Sulfinpyrazone (JP15/USP/INN); (+/-)-SULFINPYRAZONE; 1,2-Diphenyl-3,5-dioxo-4-(2'-phenyl-sulfinyl-aethyl)-pyrazolidin; 1,2-Diphenyl-3,5-dioxo-4-(2'-phenyl-sulfinyl-aethyl)-pyrazolidin [German]; 1,2-Diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl) pyrazolidine; 1,2-Diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl)pyrazolidine; 1,2-Diphenyl-4-(2'-phenylsulfinethyl)-3,5-pyrazolidinedione; 1,2-Diphenyl-4-(2-(phenylsulfinyl)ethyl)-3,5-pyrazolidinedione; 1,2-Diphenyl-4-(phenylsulfinylethyl)-3,5-pyrazolidinedione; 1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl-3,5-pyrazolidinedione; 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]pyrazolidine-3,5-dione; 4-(2-Benzenesulfinylethyl)-1,2-diphenylpyrazolidine-3,5-dione; 4-(Phenylsulfoxyethyl)-1,2-diphenyl-3,5-pyrazolidinedione; 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione
Drug Type
Small molecular drug
Indication Gout; Arthritis [ICD9: 274.00274.1274.8274.9, 710-719; ICD10:M10, M00-M25] Approved [538448], [541145], [551871]
Therapeutic Class
Uricosuric Agents
Formula
C23H20N2O3S
InChI
InChI=1S/C23H20N2O3S/c26-22-21(16-17-29(28)20-14-8-3-9-15-20)23(27)25(19-12-6-2-7-13-19)24(22)18-10-4-1-5-11-18/h1-15,21H,16-17H2
InChIKey
MBGGBVCUIVRRBF-UHFFFAOYSA-N
CAS Number
CAS 57-96-5
PubChem Compound ID
5342
PubChem Substance ID
9525, 117338, 611476, 855982, 5632696, 7847515, 8149541, 8153281, 10321460, 11112139, 11335265, 11360504, 11363916, 11366478, 11369040, 11371640, 11374587, 11377202, 11461476, 11466318, 11467438, 11485183, 11486155, 11489140, 11490406, 11492660, 11494836, 14718483, 14879380, 24899841, 26611933, 26680609, 26747070, 26747071, 29224394, 46500625, 46504918, 47216628, 47290983, 47290984, 47440092, 47588838, 48110300, 48334323, 48416577, 49698736, 50029653, 50100985, 50661502, 53789714
ChEBI ID
ChEBI:9342
SuperDrug ATC ID
M04AB02
SuperDrug CAS ID
cas=000057965
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Multidrug resistance-associated protein 1 Target Info Modulator [534903], [535143], [536584]
KEGG Pathway ABC transporters
Sphingolipid signaling pathway
Vitamin digestion and absorption
MicroRNAs in cancer
NetPath Pathway IL6 Signaling Pathway
Pathway Interaction Database S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
Reactome Cobalamin (Cbl, vitamin B12) transport and metabolism
ABC-family proteins mediated transport
WikiPathways Arachidonic acid metabolism
Irinotecan Pathway
Metabolism of water-soluble vitamins and cofactors
References
Ref 538448FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011556.
Ref 541145(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5826).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 534903Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Genomics. 1999 Sep 15;60(3):295-308.
Ref 535143Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport. J Biol Chem. 2001 May 11;276(19):15616-24. Epub 2001 Feb 21.
Ref 536584Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2). Drug Metab Dispos. 2008 Apr;36(4):631-40. Epub 2008 Jan 7.

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