Drug Information

Drug General Information
Drug ID
D03BTP
Former ID
DIB005184
Drug Name
Fosfluridine tidoxil
Synonyms
Fosfluridine; HDP-99-0006; 5-fluorouridine prodrug, Heidelberg Pharma
Drug Type
Small molecular drug
Indication Keratosis [ICD10:L57.0] Terminated [547816]
Company
Heidelberg Pharma Holding GmbH
Formula
C34H62FN2O10PS
Canonical SMILES
OP(=O)(OC[C@@H]1[C@H]([C@@H](O)[C@@H](O1)n1c(=O)[nH]c(=<br />O)c(c1)F)O)OCC(CSCCCCCCCCCCCC)OCCCCCCCCCC
PubChem Compound ID
44150338
Target and Pathway
Target(s) Thymidylate synthase Target Info Inhibitor [529580]
BioCyc Pathway Pyrimidine deoxyribonucleotides biosynthesis from CTP
Pyrimidine deoxyribonucleotides de novo biosynthesis
Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
Superpathway of pyrimidine deoxyribonucleoside salvage
DTMP de novo biosynthesis (mitochondrial)
Pyrimidine deoxyribonucleosides salvage
KEGG Pathway Pyrimidine metabolism
One carbon pool by folate
Metabolic pathways
PANTHER Pathway De novo pyrimidine deoxyribonucleotide biosynthesis
Formyltetrahydroformate biosynthesis
Pathway Interaction Database E2F transcription factor network
PathWhiz Pathway Pyrimidine Metabolism
Reactome E2F mediated regulation of DNA replication
Pyrimidine biosynthesis
G1/S-Specific Transcription
WikiPathways Trans-sulfuration and one carbon metabolism
Retinoblastoma (RB) in Cancer
One Carbon Metabolism
Integrated Pancreatic Cancer Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Metabolism of nucleotides
Fluoropyrimidine Activity
References
Ref 547816Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019549)
Ref 529580Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin. Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):733-9.

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