Drug Information

Drug General Information
Drug ID
D03AAC
Former ID
DIB021205
Drug Name
W146
Synonyms
W146_02-01; W 146; W-146
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539949]
Formula
C16H27N2O4P
InChI
InChI=1S/C16H27N2O4P/c1-2-3-4-5-7-13-8-6-9-14(12-13)18-16(19)15(17)10-11-23(20,21)22/h6,8-9,12,15H,2-5,7,10-11,17H2,1H3,(H,18,19)(H2,20,21,22)/t15-/m1/s1
InChIKey
FWJRVGZWNDOOFH-OAHLLOKOSA-N
PubChem Compound ID
6857802
PubChem Substance ID
11538027, 24257742, 26542332, 43493849, 52585244, 81080490, 90083310, 104242404, 112629136, 114696978, 117645997, 134352326, 134352328, 135651317, 144231440, 162112633, 162937021, 163893807, 212342508, 225184497, 237792791, 252157392
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Antagonist [528303]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 539949(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2931).
Ref 528303Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2(8):434-41. Epub 2006 Jul 9.

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