Drug Information

Drug General Information
Drug ID
D02ZML
Former ID
DIB019983
Drug Name
GW-5823
Synonyms
GW5823; GW 5823
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543229]
Formula
C35H33N5O4
InChI
InChI=1S/C35H33N5O4/c1-23(2)39(25-17-19-26(44-3)20-18-25)33(41)22-38-31-15-9-10-16-32(31)40(24-11-5-4-6-12-24)35(43)28(34(38)42)21-30-27-13-7-8-14-29(27)36-37-30/h4-20,23,28H,21-22H2,1-3H3,(H,36,37)
InChIKey
LGYKPDHARJMLQN-UHFFFAOYSA-N
PubChem Compound ID
5311148
PubChem Substance ID
7979483, 15062550, 39340862, 51926554, 85221690, 103251737, 103856364, 114155385, 135650337, 136351254, 139107921, 225045793, 234275606, 246611448
Target and Pathway
Target(s) Cholecystokinin receptor type A Target Info Agonist [534449]
Gastrin/cholecystokinin type B receptor Target Info Antagonist [534449]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Pancreatic secretionhsa04020:Calcium signaling pathway
Gastric acid secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR downstream signaling
GPCRs, Other
References
Ref 543229(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 865).
Ref 534449Optimization of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines as potent, orally active CCK-A agonists. J Med Chem. 1997 Aug 15;40(17):2706-25.

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