Drug Information

Drug General Information
Drug ID
D02YWV
Former ID
DIB007646
Drug Name
GR-159897
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Terminated [539340], [545424]
Company
Glaxo Group Research Ltd
Formula
C23H27FN2O2S
InChI
InChI=1S/C23H27FN2O2S/c1-28-23(17-29(27)20-5-3-2-4-6-20)10-13-26(14-11-23)12-9-18-16-25-22-8-7-19(24)15-21(18)22/h2-8,15-16,25H,9-14,17H2,1H3/t29-/m1/s1
InChIKey
BANYJBHWTOJQDU-GDLZYMKVSA-N
CAS Number
CAS 158848-32-9
PubChem Compound ID
9953599
PubChem Substance ID
14929060, 24223393, 46050208, 80327812, 134223782, 135650314, 135697628, 160703978, 241182292, 241375338, 249617281, 251961976, 252159876, 252669816
Target and Pathway
Target(s) NK-2 receptor Target Info Modulator [533707]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539340(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2115).
Ref 545424Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003215)
Ref 533707GR159897, a potent non-peptide antagonist at tachykinin NK2 receptors. Eur J Pharmacol. 1995 Jan 16;272(2-3):241-8.

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