Drug Information

Drug General Information
Drug ID
D02YBP
Former ID
DIB002209
Drug Name
Mequitamium iodide
Synonyms
LG-30435
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [544538]
Company
Laboratorio Guidotti SpA
Formula
C21H25IN2S
Canonical SMILES
[C@H]1([C@@H]2CC[N@+](C1)(CC2)C)CN1c2ccccc2Sc2c1cccc2.[<br />I-]
CAS Number
CAS 101396-42-3
PubChem Compound ID
72028
Target and Pathway
Target(s) Histamine H1 receptor Target Info Modulator [531768]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 544538Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000086)
Ref 531768High-affinity binding of mequitamium iodide (LG 30435) to muscarinic and histamine H1 receptors. Eur J Pharmacol. 1990 Jul 17;182(3):413-20.

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