Drug Information

Drug General Information
Drug ID
D02XMM
Former ID
DIB010558
Drug Name
Midaglizole
Synonyms
Midaglizole hydrochloride; DG 5218; DG-5128; Pyridine, 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]-, monohydrochloride
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Terminated [544537]
Company
Daiichi Seiyaku Co Ltd
Formula
C16H21Cl2N3O
Canonical SMILES
C(C(c1ccccc1)c2ccccn2)C3=NCCN3
InChI
1S/C16H17N3/c1-2-6-13(7-3-1)14(12-16-18-10-11-19-16)15-8-4-5-9-17-15/h1-9,14H,10-12H2,(H,18,19)
InChIKey
TYZQFNOLWJGHRZ-UHFFFAOYSA-N
PubChem Compound ID
6917709
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Modulator [533463]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 544537Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000085)
Ref 533463Studies of midaglizole (DG-5128). A new type of oral hypoglycemic drug in healthy subjects. Diabetes. 1987 Feb;36(2):216-20.

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